Is the 'tu' vs 'Voi' (regional) distinction worth stressing over for a short trip?

I’m traveling to the South of Italy soon and I keep reading conflicting advice about whether I should be worried about regional address forms. My listening comprehension is already shaky, and I don't want to accidentally offend someone or confuse them by using the wrong pronoun placement. Should I just stick to standard Italian, or will locals think I’m being stiff?